POS0841 RISK FACTORS OF LOW BONE MINERAL DENSITY IN WOMEN WITH SYSTEMIC SCLEROSIS

Background: Chronic inflammatory rheumatic diseases are risk factors of bone loss and fractures. Systemic sclerosis (SSc) has been recognized to be another potential joint disease that may affect tissue. Objectives: evaluate mineral density (BMD) low BMD in women with SSc. Methods: 173 women, among them 110 postmenopausal (median age 60[55,63] years) 63 premenopausal 35[31,44] years). was measured at lumbar spine (LS), femoral neck (FN) total hip (TH) by dual energy X-ray absorptiometry (DXA, Hologic 4500A). Low diagnosed if the T-score < -1.0 standard deviation (SD) Z-score -2.0 SD women. The relationship between SSc patients’ characteristics evaluated using univariate linear regression analysis. Results: found 66% patients: 79% - 18% Among persons osteoporosis discovered 47% osteopenia – 32% cases. In woman LS, FN TH were associated body mass index (BMI) (β=0.27, p=0.010; β=0.47, p<0,001 β=0.45, p<0,001, respectively), duration glucocorticoids (GCs) (β=-0.31, p=0.008; β=-0.34, p=0.003 β=-0.27, p=0.022, respectively); C-reactive protein (β= -0.32, p=0.016 β= -0.29, p=0.029, respectively) LS current cumulative GCs dose -0.24, p=0.039 p=0.014, respectively). BMI (β=0.51, p<0,001; p=0.002, -0.45, p=0.004; -0.47, -0.48, p=0.002; -0.51, p=0.001 -0.46, p=0.004, 25(ОН)D level (β=0.52, p=0.008 β=0.54, p=0.005, -0.44, p=0.004). Conclusion: BMI, independent for both persons. Additional as vitamin D out Disclosure Interests: None declared